Does Klinefelter Syndrome Cause Mental Retardation?

What is the survival rate of Klinefelter syndrome?

We found that Klinefelter syndrome was associated with a significant increase in mortality risk of 40% (hazard ratio, 1.40; 95% confidence interval, 1.13–1.74), corresponding to a significantly reduced median survival of 2.1 yr..

Can someone with Klinefelter syndrome reproduce?

However, problems with their testicles prevent them from making enough normal sperm to father children. The vast majority of men with Klinefelter syndrome are infertile and can’t father a child the usual way. Options for becoming natural parents are limited, but fertility researchers are working on new treatments.

How do they fix Klinefelter syndrome?

There’s no cure for Klinefelter syndrome, but some of the problems associated with the condition can be treated if necessary. Possible treatments include: testosterone replacement therapy. speech and language therapy during childhood to help with speech development.

How does Klinefelter syndrome affect intellectual development?

About 70% of patients have minor developmental and learning disabilities. These may include academic difficulties, delayed speech and language acquisition, diminished short-term memory, decreased data-retrieval skills, reading difficulties, dyslexia, and attention deficit disorder.

How does Klinefelter syndrome affect a person’s life?

But the condition can bring challenges later in life. For example, guys with Klinefelter syndrome may be more likely to get some types of cancer and other diseases, like type 2 diabetes and osteoporosis, a condition where the bones become weaker later in life.

Is mental retardation a chromosomal disorder?

In moderate to severe cases of mental retardation, 30% to 40% can be explained by known genetic or chromosomal disorders and 10% to 30% can be explained by environmental factors, leaving about 40% of cases unexplained.

What is the most common treatment for Klinefelter’s?

Treatment of Klinefelter Syndrome One common treatment is testosterone replacement therapy. It can start at puberty and can spur typical body changes, such as facial hair and a deeper voice. It can also help with penis size and stronger muscles and bones, but it won’t affect testicle size or fertility.

Will there be a Barr body in male with Klinefelter syndrome?

Like females, XXY males with Klinefelter syndrome will convert one X to a Barr body in each cell. Triple X females (as well as Klinefelter males with more than two X chromosomes) neutralize their extra Xs by forming additional Barr bodies. … XY male: one active X, one Y, no Barr body.

What is the most common cause of mental retardation?

Down’s syndrome is the most common specific cause of mental retardation, followed by the Fragile X syndrome, which mainly affects boys.

Who is most likely to get Klinefelter syndrome?

Klinefelter syndrome results when a boy is born with at least 1 extra X chromosome. This is written as XXY. Klinefelter syndrome occurs in about 1 out of 500 to 1,000 baby boys. Women who get pregnant after age 35 are slightly more likely to have a boy with this syndrome than younger women.

What does a person with Klinefelter syndrome look like?

Longer legs, shorter torso and broader hips compared with other boys. Absent, delayed or incomplete puberty. After puberty, less muscle and less facial and body hair compared with other teens. Small, firm testicles.

What age is Klinefelter syndrome diagnosed?

Diagnosis frequently occurs in adulthood; however about 75% of sex chromosome aneuploidies are never diagnosed. For suspected 47,XXY males, common indicators for karyotype analysis on peripheral blood are hypogonadism and infertility.

What is the common type of chromosomal abnormality associated with mental retardation?

X-linked forms of mental retardation are estimated to cause 10-20% of all inherited cases of mental retardation. The first gene to be identified was FMR1 that causes fragile X syndrome and still remains the commonest single gene abnormality to be identified.

What is the most common genetic cause of mental retardation?

Fragile X syndrome is the most common inherited form of mental retardation and, after Down syndrome, the most common genetic form. It is X linked, with dominant inheritance, and the penetrance is lower in females.

What are the four levels of mental retardation?

The DSM-IV classifies mental retardation into four stages based on severity: mild (IQ score of 50-55 to approximately 70), moderate (IQ score of 30-35 to 50-55), severe (IQ score of 20-25 to 35-40), and profound (IQ score of less than 20-25).

Are all Klinefelter’s infertile?

Klinefelter syndrome is one of the leading causes of male infertility. Approximately 3% of all infertile men have Klinefelter syndrome[1] and 14% of non-obstructive azoospermic men have Klinefelter syndrome[3]. Klinefelter syndrome is a chromosomal condition that affects male physical and cognitive development.