Quantiferon Tb Gold Indeterminate

What is the difference between T-spot and Quantiferon?

The T-SPOT.

TB method uses separate mixtures of ESAT-6 and CFP-10 synthetic peptides as Mycobacterium tuberculosis-specific antigens, whereas QFT-GIT uses a single mixture of synthetic ESAT-6, CFP-10, and TB7..

What does it mean when a TB test is indeterminate?

An indeterminate test result in QFT-G In-Tube test indicates that the real disease status of the person could not be ascertained. An indeterminate result is meaningful and it does not indicate a failed test.

What do you do if QuantiFERON gold is indeterminate?

The options are to repeat QFT-G with a newly obtained blood specimen, administer a TST, or do neither. For persons with an increased likelihood of M. tuberculosis infection who have an indeterminate QFT-G result, administration of a second test, either QFT-G or TST, might be prudent.

Does QuantiFERON detect latent TB?

How do you detect a latent TB infection? There are two types of tests that can detect tuberculosis infection: the tuberculin skin test (TST), also known as the Purified Protein Derivative (PPD) test, and a blood test such as QuantiFERON-TB Gold Plus (QFT-Plus).

Is latent TB contagious?

Persons with latent TB infection are not infectious and cannot spread TB infection to others. Overall, without treatment, about 5 to 10% of infected persons will develop TB disease at some time in their lives. About half of those people who develop TB will do so within the first two years of infection.

Will QuantiFERON gold always be positive after treatment?

Since most patients remained QFT-TB positive after therapy, the test should not be used to monitor the effect of preventive therapy. Prospective studies are needed in order to determine the usefulness of IGRA tests during therapy.

Will I always test positive for TB after treatment?

Even after you finish taking all of your TB medicine, your TB skin test or TB blood test will still be positive.

How is latent TB treated?

A course of antibiotic medicine will treat latent TB. You may be given Rifampicin and Isoniazid for three months (which may be together in a tablet called Rifinah) or Isoniazid by itself for six months. Your doctor or TB specialist nurse will talk you through the treatment and answer any questions you may have.

Does Tuberculosis stay in your system forever?

Many people who have latent TB infection never develop TB disease . In these people, the TB bacteria remain inactive for a lifetime without causing disease . But in other people, especially people who have weak immune systems, the bacteria become active, multiply, and cause TB disease .

Is TB Gold test reliable?

QuantiFERON-TB Gold is the most clinically tested and proven IGRA available (2). More than 30 million QFT tests have been sold across 130+ countries, including more than 7 million in 2015. Trust the only blood test for TB infection that offers: The most accurate and reproducible results for TB infection.

What if QuantiFERON TB Gold is positive?

You have a positive Tuberculin Skin Test (TST) or QuantiFERON blood test: what does this mean? If your TST (Mantoux) or Quantiferon blood test was found to be positive, this means you have a latent TB infection, but usually not the active disease.

How long is QuantiFERON gold TB test good for?

Although QFT is not recommended for confirmation of TST results, QFT can be used for surveillance <12 months after a negative tst, if the initial qft is negative.

Is QuantiFERON gold better than PPD?

The QuantiFERON (QFT) blood assay tests for tuberculosis. Patients must get their blood drawn for a QuantiFERON exam. However, QFT candidates receive exam results in 48-72 hours. Compared to PPD wait times, QuantiFERON provides a sizeable advantage.

Should you be treated for latent TB?

If they have latent TB infection, they need treatment as soon as possible to prevent them from developing TB disease. If they have TB disease, they must take medicine to treat the disease.

Is T spot the same as QuantiFERON gold?

T-SPOT uses a larger number of cells than other blood tests, such as QuantiFERON-TB Gold, as it aims to lower inconsistency and enhances sensitivity for this infection. This method also uses separate mixtures of the high- specificity TB antigens.

What if TB Gold test is negative?

Negative – suggests that TB infection is unlikely. Indeterminate – suggests the need for further investigations or repeat testing.

How accurate is TB Gold test?

The overall sensitivity for active TB was 87.5%, ranging from 62.5% in children 25–36 months old to 100% in children older than 49 months. The overall specificity for active TB was 93.6%. Among the 481 children tested for LTBI screening, 38 scored positive and all but 2 had at least one risk factor for TB infection.

What does an indeterminate QuantiFERON gold mean?

These people are deemed indeterminate by QFT, which means a result cannot be given—which is appropriate if they do not have a sufficient immune response to measure. Most people with indeterminate responses due to low CD4+ T-cells counts test negative by the TST (which does not have a control for immune status).

What can causes a false positive QuantiFERON gold?

(1) False-positive results may occur in patients with prior infection with M marinum, M szulgai, or M kansasii. Negative: No IFN-gamma response to M tuberculosis antigens was detected. Infection with M tuberculosis is unlikely.

Does latent TB become active?

The bacteria are still in your body, but they are not causing damage. However, latent TB bacteria can ‘wake up’ and become active in the future, making you ill. This can happen many years after you first breathe in TB bacteria.

Is latent TB curable?

There is no guaranteed “cure” for latent tuberculosis. “People infected with TB bacteria have a lifetime risk of falling ill with TB…” with those who have compromised immune systems, those with diabetes and those who use tobacco at greater risk.